Prospects for clinically relevant epigenetic tests in the andrology laboratory
نویسندگان
چکیده
The review published by Kläver and Gromoll is a timely reminder of the everchanging landscape of the clinical andrology laboratory as well as the limitations of current approaches to properly diagnose and treat male infertility.1 In a variety of disciplines, the clinical relevance of epigenetic status is becoming increasingly apparent. In this paper, the authors review the various studies that have evaluated the epigenetics (primarily DNA methylation) of sperm in the context of infertility, and they discuss the potential value of sperm epigenetic analysis in the workup of idiopathic male infertility.
منابع مشابه
I-4: External Quality Assessment - A Necessity in The Andrology Laboratory
Andrology laboratories need to produce reliable results for appropriate diagnostic and health care decisions. Since semen analysis is highly complex and procedurally difficult to standardize, quality control (QC) is essential to detect and correct systematic errors and high variability of results. The large discrepancies between assessments of sperm concentration and morphology in different lab...
متن کاملWhat does the clinician need from an andrology laboratory?
What does the clinician need from an andrology laboratory? The andrology laboratory is vital for the accurate diagnosis and treatment of male factor infertility, which is contributory in 50% of infertile couples. While there are some diagnostic tests of limited clinical utility, many tests can be useful in specific clinical settings. In this chapter, we will review the basic interpretation of t...
متن کاملP-116: Absence of JMJD1A, A Testis- Specific Histone Demethylase, in Tissue Samples of TESE Negative Men
Background During mammalian spermatogenesis unique and dynamic epigenetic events occur leading to chromatin condensation. Through these events, histone demethylases such as JMJD1A play important roles in compaction of sperm chromatin, due to regulation of histone methylation dynamics and alteration of chromatin structure. As �histone methylation� is one of the best-characterized modifications i...
متن کاملI-5: Semen Analysis - Clinical Laboratories; Is Standardization Applied?
Reduced semen quality is commonly claimed to be one of the main signs of male infertility and thus, analysis of semen is recommended as the cornerstone of a male fertility investigation. However, to control possible sources of physiological and methodological variation, and to generate reliable information on semen quality that can be accurately compared across different laboratories, semen ana...
متن کاملThe andrology laboratory in an Assisted Reproductive Technologies program. Quality assurance and laboratory methodology.
Assuring the highest possible quality of care to the patient is the first goal of the andrology laboratory. Quality control and quality assurance as they apply to the andrology laboratory are outlined, and special problems in quality control for sperm function assays are addressed. An example of the patient review process is presented. Quality of care also depends on the ability of the laborato...
متن کامل